I actually didnt have embryos to bring with me when we switched. Thank you TXtoCA, Im definitely planning to make changes. Unfortunately this isnt very clear at this point. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. We have some sort of make factor at play but no other known fertility issues. My doctor told me you can have an infection in the uterus and have no symptoms. ERA testing: Hi lovely people , as per - Fertility Network UK The good thing is she did not see any scar tissue during the biopsy, and the inflammation had completely cleared up. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). Sending you lots of love, hope and positivity! I may not have that exactly correct but thats how I understood it. That sounds a lot like my dr. Its basically an assembly line in there. 1st IVF Cycle with initial low beta results, Day 6 Blastocysts / PGS / embryo "Hunger Games". may be contradicted by other studies. I was doing yoga and walking everyday and meditating. He suggested an endometrial biopsy instead. I am new to the online support groups and considered joining months ago but struggled to even bring myself to put my story out there. I have expressed my concern but my RE believes it is more about the pattern. FAILED FIRST FET (Chemical Pregnancy). I have a Day 7/PGS Euploid I did acupuncture that cycle. Why do we have to wait until we have a second devastating failure? These studies were particularly small so drawing conclusions isnt really possible yet. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. I'm so sorry for your loss. Im so confused as my RE says that morphology doesnt matter if theyre euploid. We got to see and hear the heartbeat yesterday. Please whitelist our site to get all the best deals and offers from our partners. 35 years old Check here for the full. However, that information will still be included in details such as numbers of replies. But Im wondering how those numbers have changed with other advancements in infertility medicine. Any experiences with Day 6 blastocyst - Fertility Network UK Its basically a mock FET but instead of transferring an embryo they take a biopsy of your uterus to see if it was ready for implantation at the time or needs more/less progesterone. Im hoping to do another transfer in January. Any advice is greatly appreciated. For the autoimmune stuff above I was tested by Alexander Kofinas. MENTS my 3rd FET was a success end MENTS. We have our lining check on Friday. Hopefully an ERA can shed some light on it! I ended up taking Lovenox and Prednisone and doing an endometrial scratch biopsy and ERA. Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. Yes, and I believe it was due to doctor negligence. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. definitely worth asking! A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). Im sorry that didnt work. Why did I miscarry a normal embryo? Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. Sending you positive thoughts . This isnt very surprising considering these embryos have no cells that are euploid in order to self-correct (read more about that here). We started some workup with my OB (TSH, karyotyping and carrier testing). I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. There are many potential causes of an . , dont be sorry! One thing Ive definitely learned from all of this is to trust my gut instinct. Question about blastocysts and PGS testing - we got 12 eggs / 7 mature / 7 fertilized with ICSI and 2 grew to 6 days. Wondering if anyones had a similar experience or has any advice. I know how hard this all is. Medication wise other than the standard progesterone and estrogen and prenatal I also did take aspirin 81mg. I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. So all the aneuploid embryos that were transferred either didnt implant, or miscarried. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. MENT I got a natural BFP at 34yo with an FSH of 38 and had no issues with my pregnancy. While a PGS normal embryo means the chromosomes are normal, there is more to a baby than just chromosomes and sometimes it just doesnt work. Is it significantly less for a pregnancy with an embryo that tested pgt normal? Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. Its so heartbreaking but Im trying to find some hope so I can move forward. Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. My second Beta I dropped to 59. Your post will be hidden and deleted by moderators. I just don't know what to do. Find advice, support and good company (and some stuff just for fun). We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! So what gives now?? Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. It was a chemical pregnancy. So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. They may be able to use the same sample as the ERA if you do both. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. Note that once you confirm, this action cannot be undone. If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. After each failed transfer, my RE did a lot of additional testing including a Yale EFT biopsy for receptivity and a clotting test to see if I needed lovenox and/or baby aspirin. thats a great suggestion! More high quality studies need to be performed to really see the answer to this question. I am currently 6w5d pregnant, which is the farthest Ive been. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. Ill have to ask my RE for options. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. Limitations of PGS | IVFMD Can any further conclusion be made based on number of normal pgs results ? Disclaimer: Any studies presented here may be contradicted by other studies. Chemical Pregnancy: What it is, Symptoms, and More - WebMD PGS can increase the rate of clinical pregnancy. I know she's going to ask me whether I want to proceed or not unless these 3 follicles really change overnight, of which I'm not getting my hopes up. MENTS THROUGHOUT MENTS Im absolutely going to ask for biopsy and check for endometritis. Thank you Its so hard when youre paying yet your doctor doesnt think its needed. Only one normal PGS embryo - any advice on preparing for - Inspire (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. Segmental mosaics or single chromosome mosaics tend to perform better than multiple chromosome abnormalities which can approach 50% miscarriage rates. How does PGS improve IVF success rates? - Infertility Aide I have a whole page dedicated to mosaic embryos. wow, Im so glad you were able to get a second opinion. Live birth rate differences are inconsistent and therefore inconclusive. PGS testing (aka PGT-A) is a technique to help choose the best embryo for an embryo transfer. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Even though I ended up with no good embryos I recommend it because I think it's good to know now and not later with a miscarriage. Aluko et al. They biopsied those 2 embryos and send off the cells for PGS testing. And since then Ive had medical issues that havent allowed me to try again until last month. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. Alternatively you can check out my websites tag for mosaic embryos here. So the advantage with PGT-A may be in determining which embryos are completely unfit for transfer, at least based on this study. So the next step is transfer and my clinic is telling me to go for era in order to increase my chances. I just officially confirmed another Chemical pregnancy for me. At the time, I was at rock bottom and going to an online support group. Statistically speaking it takes an average of two transfers before a successful pregnancy. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. They also reported the number ofblastsbiopsied. Besides that, there are no gaurantees of both sticking. Mosaics are embryos that have a mix of euploid and aneuploid cells. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. This was our first trial. . There is much better chance of IVF success with PGS testing in women who were over the age of 35. They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. Dr is responsible for allowing . Next lets look at how mosaics perform in terms of miscarriage (often using euploids as a control so for you euploid people out there, you might want to check the next section also!). , Ive done embryo glue every transfer but no luck unfortunately :(. Terms are highlighted every 3rd time to avoid repetition. I feel like most times the protocol for autoimmune issues is the same. Some of the reasons quoted werent even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, theres a margin of error with the testing itself, pgs doesnt tell us everything about an embryo, etc. Also - wanted to add that I think my husband and I both did antibiotics still with our new clinic. I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. The test uses an algorythm and brings together age (in my case 44), the nuchal measurement of the foetus (which was normal) and the values of PAPP-A and Beta HCG from a blood test. Im assuming you had no issues shipping yours? (I was taking baby aspirin and Lovenox 2x/day for blood clotting disorders as well as Prednisone 30 mg /day and Intralipid transfusions weekly for elevated NK cells). My clinic does allow each patient to continue with one retrieval with only 1-2 follicles, however, for cost reasons since we're doing ICSI and PGS testing I'm considering cancelling the cycle. PGT-M and PGT-A Genetic Screening Before IVF - Verywell Family My 2nd also failed and I had them do a thrombophilia panel on me and found I had a MTHFR mutation so we added folgard and he adjusted my days on progesterone and in addition to the suppositories I did the shots as well. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. Is it because they were early blastocysts? And Im so sorry about your first FET. Chemical pregnancies occur so early that many people who miscarry don't realize it. undefined will no longer be visible to you including posts, replies, and photos. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Dear T3BK, thank you so much for your reply! Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). Or adding an immune protocol if you didnt with this FET. How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility Another study agrees with these data (Franasiak et al. Its not a ton of time to do and it might make the difference. Or is it worth having the actual tests done? no, I just took those 3. Early Pregnancy Loss - Miscarriage Doctor in Los Angeles - USC Fertility We are currently looking to use a gestational surrogate in Texas. For women who have it, REs may suggest prednisone and lovenox after transfer. I am so frustrated, disappointed, hurt, sad and angry right now. Gearing up for FET thanks so much! Are you sure you want to block this member? IVF is a numbers game. For more background info, check out my post onPGS Testing. No clinic ended up quoting more than 60-70% . Mosaic embryos can be either low- or high . I only have embryo left ugh . If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? Mosaics are often transferred after euploid embryos have been exhausted, although there is evidence that low level mosaic transfers are comparable to euploid transfers (see here for a review). Last year I got pregnant from an IUI and miscarried at 8 weeks. How PGS can Improve Success Rates with Chromosomally Normal Embryos More info in my profile about my testing and treatment, and Im open to answering any questions. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. For now its probably best to avoid having to thaw and biopsy if possible. Note that this paper is still preprint as of Nov 2021. thank you for sharing! Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. Bradley et al. With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. 2 came back normal. An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. Thanks for sharing! I'm super bummed about it being a chemical, but I still feel like progress was made because this was my first positive pregnancy test EVER. Obviously, when we look at transfer rates with PGS tested embryos, we are not including all the women who didnt have anything to transfer. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. If it's any consolation, we also did acupuncture with the failed FET, but not the one that worked. I am just torn. Most of the patients in the studies were <35. She said that this is something that is prevalent in recurrent pregnancy loss and failed implantations. Second, PGS speeds up the time to pregnancy. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Chemical pregnancy facts. This educational content is not medical or diagnostic advice. 12 43 comments Best Add a Comment gundacurry 2 yr. ago https://www.fertstert.org/article/S0015-0282 (17)31371-7/fulltext lennylincs 2 yr. ago Good luck and feel free to PM me. - continued the same above protocol with the only change was that once I got my first positive beta (63) they had me increase the progesterone suppository to three times a day. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). I wanted to point out thestandard deviationof this data is large, roughly 30% for each group. Success rates with chromosomally normal embryos, complete guide to embryo grading and success rates, https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates, They also found that the chance of getting a complex abnormal embryo increased with age, Graded as excellent (AA) or good (AB or BA) = 50% live birth, Graded as excellent: 84%ongoing pregnancy, 0% miscarriage, Good: 62%ongoing pregnancy, 3% miscarriage, Poor: 36%ongoing pregnancy, 19% miscarriage, Thaw the embryo and culture it until it can be biopsied (this may take a few hours to a day), If the 2nd test comes back euploid and you transfer, another thaw will need to be done. Why I Gave My Mosaic Embryo a Chance - The New York Times So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. Best of luck to you with your upcoming FET, my thoughts and prayers are with you! Check here for the full. Did anyone else have success after failure with PGS? You guys have given me so much support and reassurance that I'm not alone in this ordeal. I feel so lucky that I found this community. About 7 months later I transferred a day 7. END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? Please whitelist our site to get all the best deals and offers from our partners. my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. So, all is well! Id say if you feel you want the extra testing, push for it. END MENTS We really expected to find success with our first pgs transfer even though our company and RE only quoted 60% odds per embryo transferits a good but tough reminder that its not expected to always work. Pregnancy rates will be higher because not everyone will have a live birth (some miscarry). thank you for sharing your success story! Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). Hoping to hear from them soon . My doctor thought it was possibly due to retained products of conception. Terms are highlighted every 3rd time to avoid repetition. The antibiotics were pretty strong, but I think they upset my stomach more than they did my husband. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Whitney et al. Design: Case-control study. Im so sorry for your losses. Consult with your doctor before making any treatment changes. Trying naturally, assisted, etc. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). Took 2 years of "fighting" but looking back all the money, pain. PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . I am hoping number 5 is it. Thanks so much in advance for any feedback. I can't tell if that is from the progesterone. It took me 3 fresh + 3 frozen but I finally did get my baby. Best of luck to you. I expect a call from my RE tomorrow, will ask about both of your suggestions, the immune protocol and antihistamine and see what she thinks . Im very sorry and hope you can find the strength to continue. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. I have a similar story. It is seriously invaluable to me. He also answers questions in his private Facebook group. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. We have not done a hysteroscopy but will ask my dr if we can do one to check and at least rule that out. For your second question, Ill be doing an Embryo News this week that explains a study that compares non-PGS vs PGS tested embryos. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). As someone else mentioned adding prednisone, I also had a steroid but mine was the Medrol Dose pack which is basically the same idea. Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. All the comments on here seem pretty helpful already. I was exactly like you- I told myself and my RE that I refused to go through that devastation again so I wanted to do everything possible to make the outcome different. Low mosaics had a miscarriage rate of 11.0%, None of these were statistically significant from the other (, Euploid embryos had an 8.6% miscarriage rate, All of the mosaics had a 20.4% miscarriage rate, <50% mosaic segmental embryos had a 13.6% chance of miscarriage, >50% mosaic segmental embryos had a 20.3% chance of miscarriage, <50% two whole chromosome mosaics had a 11.9% chance of miscarriage, <50% complex (>2 whole chromosomes) mosaics had a 26.7% chance of miscarriage, >50% two whole chromosome mosaics had a 39.9% chance of miscarriage, >50% complex (>2 whole chromosomes) mosaics had a 44.3% chance of miscarriage. They havent discontinued my medication they want me to continue until further instructions. Has anyone ever gotten lucky and had all embryos come back normal? This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. I've read that in a non-IVF pregnancy, the rate of miscarriage is about 21.3% between weeks 5 and 6.

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