Letrozole 2 5 mg Uses, Side Effects and Dosage

Vaginal lubricants and moisturizers (longer-lasting forms of moisturizers) can help with these concerns. Talk to your healthcare team for more suggestions for managing this side effect. Letrozole is a medicine that is used to treat breast cancer in menopausal women. It works by reducing the production of a hormone, estrogen that is present in the body.

• Aromatase is the enzyme responsible for the conversion of testosterone to estrone (E1) and of androstenedione to estradiol (E2).
• Allresponses were confirmed by a second evaluation 4 to 12 weeks after the documentation of the initial response.
• Based on studies in male animals, Femara may impair fertility in males of reproductive potential see Nonclinical Toxicology.

What is breast cancer?

About 1/3 of the patients were greater than or equal to 70 years old. In the first-line study, patients greater than or equal to 70 years of age experienced longer time to tumor progression and higher response rates than patients less than 70. In a postnatal developmental toxicity study in lactating rats, letrozole was administered orally at doses of 1, 0.003, 0.03, or 0.3 mg/kg/day on Day 0 through Day 20 of lactation. The reproductive performance of the male offspring was impaired at letrozole dose as low as 0.003 mg/kg/day (approximately 0.01 times the maximum recommended human dose on a mg/m2 basis), as reflected by decreased mating and pregnancy ratios. During treatment or within 30 days of stopping treatment (median duration of treatment 60 months), the incidence of cardiovascular events was 9.8% for letrozole and 7.0% for placebo. Based on 62 months median duration of follow-up in the randomized letrozole arm in the safety population the incidence of new fractures at any time after randomization was 13.3% for letrozole and 7.8% for placebo.

Differences in letrozole pharmacokinetics due to race have not been studied. The background risk of major birth defects and miscarriage for the indicated population is unknown. However, the background risk inthe U.S. general population of major birth defects is 2%-4% and of miscarriage is 15%-20% of clinically recognized pregnancies.

What are side effects of Letrozole?

Their risk is higher because of the cancer itself and some treatments for breast cancer. If the cancer has spread to other parts of the body (secondary breast cancer), this also increases the risk. Cancer-related fatigue is extreme tiredness that doesn’t go away with rest or sleep. It’s a very common side effect of breast cancer treatment and may affect you physically and emotionally.

Talk to your care team about the use of this medication in children. Ask your pharmacist any questions you have about refilling your prescription. Your doctor may order certain lab tests to check your body’s response to letrozole.

After the unblinding of the study at a medianfollow-up of 28 months, approximately 60% of https://www.rematesmarini.cl/2024/12/31/stanos-stanozolol-10-mg-elbrus-pharmaceuticals-19/ the selected patients in the placebo arm opted to switch to Femara. Adverse reactions were analyzed irrespective of whether a symptom was present or absent at baseline. Most adverse reactions reported(approximately 75% of patients who reported AEs) were Grade 1 or Grade 2 applying the Common Toxicity Criteria (CTC) Version2.0/Common Terminology Criteria for Adverse Events (CTCAE), Version 3.0. Table 1 describes adverse reactions (Grades 1-4 andGrades 3-4) irrespective of relationship to study treatment in the adjuvant trial for the monotherapy arms analysis (safety population). Femara (letrozole) is indicated for the adjuvant treatment of postmenopausal women with hormone receptor positive earlybreast cancer.