Methylprednisolone sodium succinate has the same . Contact us at info@Bacteriostaticwater.com, Bacteriostatic Water vs. Sterile Water: The Differences That Can Save Your Life. The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. The packaged diluent (Bacteriostatic Water for Injection) contains benzyl alcohol as a preservative. It is a copolymer of ethylene and propylene. Plus, peptide solutions made with bacteriostatic water resist contamination. Bacteriostatic water is very easy to manufacture while sterile water is an arduous process. If you dont know what BPC 157 is, it is a peptide that is used by athletes and bodybuilders to recover from injuries and aid in the healing process. Prior to buying anything, check that it is compliant where you live with your current government laws. False Dr. Fouda uses his extensive knowledge and expertise as a neurosurgeon to medically review articles for accuracy and credibility, ensuring that the information presented is up-to-date and trustworthy. Plus, peptide solutions made with bacteriostatic water resist contamination. Bacteriostatic Water for Injection Prescribing Information. Inspection Technical Guides, Recalls, Market Withdrawals and Safety Alerts, Inspections, Compliance, Enforcement, and Criminal Investigations. Read more. The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Lysis is the breaking down of a cell or membrane. On the other hand, a sterile water vial doesnt contain any preservatives/additives which can keep it free of pathogens for a longer time, thus one will have to use it immediately after opening the seal. Do not use unless the solution is clear and seal intact. Differences Between Bacteriostatic Water vs. Sterile Water However, when excipients or other additives are present, weight variation may be applied provided there is correlation with the sample weight and potency results. Distilled water is a form of sterile water but sterile water is not always distilled! Bacteriostatic Water is a prescription medicine used to dilute or dissolve medications. Unfortunately, piping such as that for the administration of inert gas (usually nitrogen) and sterile air for backfill or vacuum break are often inaccessible to such surface "sterilization" or treatment. Reconstitution. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. SIDE EFFECTS. The choice is purely up to the user which solution to use. IMPORTANT Use only the accompanying diluent or Bacteriostatic Water For Injection with. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. Because it is vulnerable to contamination, it is sold in single-dose containers [5]. Using either in the proper conditions can provide extraordinary results. A major concern with the filling operation is assurance of fill volumes. See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS. These two solutions are sterile water and bacteriostatic water. Complement your research with this USP solvent, the go-to solution of the medical and scientific community. if a dosage is say 20mcg of each individually, wht is a dosage of the mix? Use only as a diluent or solvent. The semi-rigid vial is fabricated from a specially formulated polyolefin. Reconstitution Solution 4-Pack (30mL) Bactostatic Labs. Water for Injection, USP is chemically designated H2O. While you can go on to use the conventionally manual way to reconstitute peptides, it gets a whole lot easier to use the reconstitution calculator, and get the right dosage! The container requires no vapor barrier to maintain the proper labeled volume. This can come into play when preparing for traveling, budgeting monthly expenses and storage. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. 1996-2023 RxList, Inc. An Internet Brands company. LTD.Salt Lake Electronics ComplexEP Block, Sector V, BidhannagarKolkata, West Bengal 700091, INDIA. Using in such a matter can cause hemolysis or destruction of red blood cells. For more information, please see our For these types of products, bioburden should be minimal and the bioburden should be determined prior to sterilization of these bulk solutions prior to filling. Note that you should absolutely not stir or shake the vial as it is going to damage the peptide and it will no longer be effective. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. Both meet US Pharmacopeia (USP) standards. Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP containing additives should be given to a pregnant woman only if clearly needed. The concern with any microbiological level is the possible increase in endotoxins that may develop. Both have similar uses and are sterile but have drastically different demographics and indications. Sterilization procedures should parallel that of an autoclave and a typical system should include: Provisions for sterilizing the shelf support rods unless they are only exposed to the inside of the chamber after stoppering. The safety and effectiveness of Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection, USP have not been established in pediatric patients. These include subcutaneous, intramuscular, intravenous, and intradermal injection routes [. The safety and effectiveness of Bacteriostatic Water for Injection, USP have not been established in pediatric patients. Unlike a powder or liquid fill, a low fill would not be readily apparent after lyophilization. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. .063 mg/mL, 3200 mL c. 1000 mg/mL, 5 mL d. 64 mg/mL b. All you have to do is add the desirable reconstituted peptides in 1 vial and then use the syringe to pull out the mixture so that you can administer it. Reconstitution Solution versus Bacteriostatic Water I need to rehydrate some BPC, but when I look for bacteriostatic water on Amazon, it takes me directly to "reconstitution solution." If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Peptide Reconstitution + Mixing Guide with Calculator, Read the full review on BPC 157 only at Muscle and Brawn, Limitless Life Nootropics (and Peptides) Review, Epitalon Peptide Guide: Benefits, Uses, Dosage, How to Safely Use SARMs to Sculpt Three-Dimensional Muscles and Torch Fat, The ONE Thing You MUST do Before starting SARMs if You Want to Keep Yourself Out of the Hospital, The MILDEST SARM that gives you gains without all the bloating, How to Properly Use SARMs to build 3D Muscles Without Experiencing Sloppy Noodle Syndrome. Please enter the email address for your account. Bacteriostatic water differs from sterile water by the addition of benzyl alcohol as a preservative with a final concentration of 0.9%. In a nutshell, in order to make the 1 proper dosage of BPC-157, you would need to draw 10 units of water and then mix it by following the reconstitution guidelines. Because they are antibiotics, low bioburden of these formulations would be expected at the time of batching. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Medically reviewed by Drugs.com. Bacteriostatic Water is available generically and has the same name. One would be used to control and record temperatures of the cycle as with sterilizers, and the other would be in the cold spot of the chamber. Withdraw approximately 1mL of bacteriostatic water from the vial and slowly transfer it into the peptide container. The video I would recommend is embedded below. [See USP Controlled Room Temperature. Muscle + Brawn 2023. Because of the potential toxicities associated with Bacteriostatic Water for Injection, many hospitals only utilize WFI. The universal rule is to use 1 milliliter of bacteriostatic water for every peptide that you reconstitute. Deus Medicalbelieve in completing the challenges usually faced by pharmaceutical companies in India. Cookie Notice Call your doctor for medical advice about side effects. This information, including any referenced scientific or clinical research, is made available for educational purposes only. Bacteriostatic Water vs reconstitution solution whats the difference? This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Their pH levels and chemistry are distinct. With a deluxe kit, you will have all you need for safe injections at your disposal. Bacteriostatic 0.9% Sodium Chloride (NaCl) Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Always use as directed on the label. Our content is continually monitored by an internal peer-review process to ensure accuracy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. Research peptides present great potential in emerging clinical contexts, such as combating symptoms of cardiovascular and metabolic diseases, as well as improving reproductive health [11]. Bacteriostatic water solutions remain sterile and safe for longer due to the preservative agent. Allow the powder to naturally dissolve until the vial is transparent. Most peptide packages contain mixing instruction. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Some of the older lyophilizers cannot tolerate steam under pressure and sterilization is marginal at best. Penetrate the peptide vial as gently as you can. Somatropin should not be used for. Last but not least, use plastic storage containers made up of polypropylene as it is chemically resistant and there is usually no fear of breaking/spilling as well compared to glass containers. To make it easy for you to get the best materials, the Peptides.org team has perused the web and selected the single best online source for your injection material requirements: This trusted vendor has an impressive selection of full research kits for your convenience. I'm diluting my AA (vinegar) to get to 0.6% AA. The starter set has all you need to get going, including the following: If you want a little more, check out the premium kit: Qualified handlers are sure to enjoy this top online source for research materials. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Your best option for assembling the necessary tool kit is a single, reputable source. These are not all the possible side effects of Bacteriostatic Water. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. 11, pp. These Terms will be applied fully and affect to your use of this Website. You can email the site owner to let them know you were blocked. Bacteriostatic water and sterile water can be used in intravenous, intramuscular and subcutaneous injections. Also, nothing contained on this Website shall be interpreted as advising you. Any transfer and handling, such as loading of the lyophilizer, should take place under primary barriers, such as laminar flow hoods under which the vials were filled. RxList does not provide medical advice, diagnosis or treatment. Nothing really. Sterile water is water that has no additives or preservatives added to it. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. 5.0 out of 5 stars Good product. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! ZOMACTON 10 mg reconstituted with bacteriostatic water for injection containing 0.33% metacresol should not be used if the patient is allergic to metacresol. FDA indications vary regarding drug interactions. Minors or people below 18 years old are not allowed to use this Website. The container can be re-entered multiple times (usually by a sterile needle) and the benzyl alcohol is added to ensure that bacteria does not grow in the water as diluting medications with tainted water can have some severe consequences. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. These Website Standard Terms and Conditions written on this webpage shall manage your use of this website. Due to the potential for toxicity, solutions containing benzyl alcohol should not be used in neonates. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. pH of the reconstituted solution is within the USP specified range of 7 to 8 and the tonicities are, for the 40 mg per mL solution, 0.50 osmolar; for the 125 mg per 2 mL solution, 0.40 osmolar; for the 1 gram per 8 mL solution, 0.44 osmolar; for the 2 gram per 30.6 mL solutions, 0.42 osmolar. 3977). The benzyl alcohol in it would cause red blood cell lysis. We strive to never have a piece of inaccurate information on this website. Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. Overdose & Contraindications OVERDOSE Use only as a diluent or solvent. Create your account and enjoy a new shopping experience. The re-use of sterile water for injections is strictly prohibited. Store at 20 to 25C (68 to 77F). Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. All of our content is written by people with a strong science background, including medical researchers. What is bacteriostatic water? However, this method requires special equipment and expertise. Verified Purchase. It is a copolymer of ethylene and propylene. Both have the dangerous side effect of hemolysis when injected alone. Contraindications for bacteriostatic water injections include newborn babies and cerebrospinal injections [2, 8]. For intravenous infusion, first prepare solution by adding not more than 2 mL of Bacteriostatic Water for Injection to the vial; this solution may then be added to 100 . The clinical applications of the hormone hCG include fertility enhancement in both women and men, as well as a supplement to TRT in male subjects [17, 18]. RedwolfWV Registered User Awards 1 May 24, 2008 #4 Ahh I get it. Additionally, this stability testing should include least concentrated as well as the most concentrated reconstituted solutions. Now, before you start flexing your peptide muscles, you need to learn the proper way to reconstitute them. Sterile water is formulated for irrigation, such as rinsing wounds, unlike bacteriostatic water. Intravenous administration of Bacteriostatic Water for Injection without a solute may result in hemolysis. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. Data are unavailable on the toxicity of other preservatives in this age group. Once you open the seal of the sterile water vial, you will either have to use it preferably within the next 4 hours or discard it. Obviously, a low fill would represent a subpotency in the vial. It is considered an ideal sterile solution due to its low toxicity and minimal interference with drug effectiveness. While there is not a long-term shortage, an acute shortage is often seen because of either manufacturing facilities malfunction or some medical emergency such as COVID-19. I have this same question. 5.161.53.20 But not all peptides dissolve in water easily, so it usually is recommended that you try to dissolve the peptide in any of these waters using Sonication. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. See WARNINGS, PRECAUTIONS Bacteriostatic water formulations for injection have pH levels of 4.5-7, averaging 5.7. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. The pH is 5.7 (4.5 to 7.0). With the presence of 0.9% benzyl alcohol, the shelf-life of a bacteriostatic water vial is considerably increased up to 28 days as it will prevent the growth of any bacteria. 2) Decide how much reconstitution liquid you want to use to convert your lyophilized peptide into an injection-ready solution, and calculate the concentration of the solution. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Also, there should be provisions to isolate particular sections of the filling operations when low or high fills are encountered. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Both act as dilutants or solvents of substances to enable injection. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Bacteriostatic water is water with benzyl alcohol. Bacteriostatic water is contraindicated, or forbidden, from being used in neonates, newborns in the first 28 days of their life. Bacteriostatic Water for Injections | The A-Z Guide, Add a header to begin generating the table of contents.
